Studies of the Right Ventricular Response to Therapy in Patients with Pulmonary Arterial Hypertension
The
Cardiovascular Medical Research and Education Fund is seeking proposals from qualified academic medical centers with the ability to coordinate and conduct a clinical study evaluating right ventricular function in patients with pulmonary hypertension, its adaptive and maladaptive responses, and the effects of therapy.
- Study hypotheses: Maladaptation to the pulmonary hypertensive state is largely responsible for right ventricular failure in chronic pulmonary hypertension. Changes that occur in the right ventricle predict clinical improvements in patients undergoing treatments for pulmonary hypertension. The applicant is requested to propose one or more related hypotheses that will be tested in this study.
- The patient inclusion criteria for the study should include Category 1 pulmonary arterial hypertension, in which a new or additional medical therapy is clinically indicated.
- The follow-up assessments should be over 6 months, and patient enrollment should be completed within a 2 year period.
- The state of the right ventricle should be characterized with multiple parameters that will provide insight into the adaptive and maladaptive state, and reflect changes that occur from therapy that will further the understanding of how therapies may work.
The deadline for grant submission is July 1, 2012. Funding will begin October 1, 2012. All applicants are requested to submit a letter of intent with a brief description of their proposal, and the collaborating institutions.
Letters of intent are due by April 1, 2012. Funding is available to Canadian institutions. The current NIH RO1 grant application format is suitable for formatting the application. Indirect costs to institutions will be offered at 20% over direct costs.
The direct award for this study will be limited to $2 million, inclusive of all subcontracts.
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